Although the former NKp80- subset had not been reported so far in HD, it has been described that following in vitro stimulation with PMA or a cocktail of cytokines (IL-2+IL-12+IL-18), NK-cells might downregulate NKp80 expression, as also confirmed here after short-term in vitro stimulation, suggesting that downregulation of NKp80 might induce a negative regulatory circuit loop that would facilitate autonomous control of NK-cell responses during inflammation and infection (26). The gene discussed is IL18; the disease is Huntington disease.