Intriguingly, genes such as Ifi204, Irgm1/2, Nos2, Gbp3/7, Usp18, Irf7, Stat1, and Isg15, which were upregulated in response to infection in cells treated with siR_Ctrl, showed decreased upregulation in cells treated with siR_Nostrill following infection. The gene discussed is NOS2; the disease is infection.