Intriguingly, knockdown of Nostrill with the siRNA in IEC4.1 cells resulted in a significant suppression of IFN-γ-mediated epithelial defense, reflected by a higher infection burden in siR_Nostrill-treated and IFN-γ-primed cells compared with that in IFN-γ-primed cells treated with the siR_Ctrl (Figure 4D). The gene discussed is IFNG; the disease is infection.