COTL1 was found to be markedly upregulated in lung cancer (Jeong et al., 2011; Guo et al., 2017), breast cancer (Pei et al., 2020; Wang et al., 2022) and glioblastoma (Shao et al., 2020) but was downregulated in liver metastases of colon cancer (Kim et al., 2019). This evidence concerns the gene COTL1 and breast cancer.