COTL1 was found to be markedly upregulated in lung cancer (Jeong et al., 2011; Guo et al., 2017), breast cancer (Pei et al., 2020; Wang et al., 2022) and glioblastoma (Shao et al., 2020) but was downregulated in liver metastases of colon cancer (Kim et al., 2019). Here, COTL1 is linked to malignant colon neoplasm.