COTL1 was found to be markedly upregulated in lung cancer (Jeong et al., 2011; Guo et al., 2017), breast cancer (Pei et al., 2020; Wang et al., 2022) and glioblastoma (Shao et al., 2020) but was downregulated in liver metastases of colon cancer (Kim et al., 2019). The gene discussed is COTL1; the disease is colonic neoplasm.