• Promotes the survival of macrophages via an IL-6/STAT3-dependent pathway• Visfatin-Notch1 axis contributes to breast tumor growth through the activation of the NF-κB pathway• Activates AKT/PI3K, and ERK/MAPK.• Produces lipids through the EGFR/PI3K/AKT/GSB3β/SREBP-1 signaling pathway. The gene discussed is NFKB1; the disease is breast neoplasm.