TP53 and neoplasm: It directly promotes tumor cell proliferation, migration and invasion, inhibits apoptosis and indirectly influences tissue sensitivity to insulin, inflammatory responses, and angiogenesis as it controls the expressions of several factors that are important for carcinogenesis, including cyclin D1, p53, survivin, E-Cadherin, vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) (Sanchez-Infantes et al., 2014; Nepal et al., 2015).