Wang et al. also demonstrated that BMSCs-derived exosomal Kruppel-like factor 4 (KLF4), by targeting obesity-associated protein (FTO), can promote the expression of long noncoding RNAs (lncRNAs) and supress N6-methyladenosine (m6A) modification of dynamin-related protein 1 (Drp1). Here, KLF4 is linked to obesity due to melanocortin 4 receptor deficiency.