IL18 and diabetic kidney disease: Then we detected the NOD2 signaling pathway in podocytes and diabetic mice, our results showed that high glucose upregulated the expression of NOD2 as well as its downstream protein p-RIP2 and p-P65, resulting in the increase of inflammatory factors such as TNF-α, IL-6, IL-1β, and IL-18; in vivo, DKD mice had high expression of above proteins and inflammatory factors, our results were consistent with previous research that NOD2 is overexpressed in DKD.