Third, based on two large‐scale prospective cohort studies, our molecular pathological epidemiology database could assess the features of KRAS c.34G>T‐mutated colorectal cancer, including the prognostic role of this specific KRAS c.34G>T mutation independent of BRAF mutation and many other various clinicopathological and tumoral features. The gene discussed is BRAF; the disease is colorectal cancer.