As shown in Figure 5A,B, compared with the model group, the celastrol treatment and the Mdiv‐1 treatment alleviated the imbalance of P‐Drp1, Fis1, Mfn1 and Mfn2 expression and reduced the expression of P‐Drp1 (S616) in AD mice. The gene discussed is MFN2; the disease is Alzheimer disease.