In conclusion, our study clarified that RBM15 affected the expression of GPX4/ACSL4 by the KDM5B/FER1L4/KCNQ1OT1 axis through IGF2BP3-dependent m6A modification, thereby inhibiting ferroptosis and promoting DDP resistance of LC cells. Here, IGF2BP3 is linked to laryngotracheoesophageal cleft.