Although there are currently no reports on KDM5B regulating cancer through ferroptosis, a study has shown that inhibiting KDM1 can reduce GSH production through H3K9me2 modification and enhance lipid peroxidation and ROS accumulation, thus increasing ferroptosis and exhibiting anti-tumor effects on non-small cell lung cancer [48]. The gene discussed is KDM5B; the disease is non-small cell lung carcinoma.