INS and Insulin resistance: The secondary outcomes consist of changes in anthropometric parameters, indirect calorimetry parameters, lipid profile (triglyceride, total cholesterol, LDL, and HDL), liver enzyme tests (AST, ALT, and ALP), FBG and insulin concentrations, insulin resistance (assessed by HOMA-IR) [19], appetite status, cognitive outcomes (assessed by GNG test and WCST), quality of life assessment (WHOQOL-BREF questionnaire), sleep quality (PSQI questionnaire), physical activity assessments (IPAQ and pedometer), and 3-day food and drink diary.