Familial defects in apolipoprotein B-100 are caused by variants in APOB, familial hypercholesterolemia is caused by variants in the LDL receptor (LDLR), and non-FH/non-FDB hypercholesterolemia is caused by variants in PCSK9. Furthermore, lipid storage disorders other than cerebrotendinous xanthomatosis (CTX) rarely result in neurological damage. This evidence concerns the gene APOB and familial hyperaldosteronism.