According to the sensitivity analysis, a higher energy-adjusted DII score was positively associated with osteoporosis risk (Ptrend=0.008, Table S1), and elevated levels of IL-6, IL-10, IL-12p70, IL-17, and IL-23 were also associated with increased osteoporosis risk (P < 0.05, Table S2). The gene discussed is IL17A; the disease is osteoporosis.