Unlike cases of severe 17-OHD that may lead to cortisol deficiency and the adrenocorticotropic hormone (ACTH) induced compensation that may lead to prebottleneck hyperaldosteronism and the associated hypertension and hypokalemia, both patients presented had a mild 17-OHD, and had no clinical cortisol deficiency or hyperaldosteronism. This evidence concerns the gene POMC and hypertensive disorder.