GLP-1 RA did not decrease the rate of atrial fibrillation in the pooled effect size (OR 1.02; 95% CI 0.52, 2.01; p = 0.95; I2 = 16%) (Fig. 4) (Hulst et al. 2019; Besch et al. 2017; Holmberg et al. 2014; Lipš et al. 2017; Sokos et al. 2007). This evidence concerns the gene GCG and atrial fibrillation.