To explore the potential underlying mechanisms, the study performed mediating effect analyses, which revealed that ApoA1/ApoB partially mediated the association between the PCSK6 rs1531817 polymorphism and coronary artery stenosis severity, and TC/HDL and TVD partially and in parallel mediated the association between the PCSK6 rs1531817 polymorphism and MACEs. Here, PCSK6 is linked to coronary stenosis.