Meanwhile, the Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin (SCARLET) failed to determine the efficacy of rhTM in patients with sepsis-associated coagulopathy, which was defined as PT-international normalized ratio (INR) > 1.4, platelet count of 30–150 × 109/L, or a decrease in platelet count > 30% within 24 h [43]. The gene discussed is THBD; the disease is Sepsis.