However, spontaneous abortion and preterm labor were the only pregnancy adverse outcomes affecting women of Group-C (IgM+/IgG+), while women of Group-A (IgM-/IgG-) had higher incidence of complications that mainly develop with continued pregnancy as gestational diabetes, gestational hypertension and premature rupture of the membrane, while the frequency of these complications for women of Group-B was low and absent for women of Group-C who had higher frequency of early pregnancy loss (Table 2). This evidence concerns the gene CD40LG and preeclampsia.