However, no significant difference in BDNF levels was observed between the depressive control and normal control groups (p = 0.996).Lee et al. [20] reported that BDNF levels between MDD and normal control groups exhibited good discriminatory power using ROC curve analysis (AUC = 0.774; 95% CI 0.663 to 0.884; sensitivity = 78.3%; specificity = 81.3%; cutoff = 684.75). This evidence concerns the gene BDNF and major depressive disorder.