When considering the secondary outcome, an increased NTproBNP was associated with a statistically significant increased risk of all-cause mortality HR 2.41 (95% CI, 2.25, 2.57) ); stroke HR 1.45(95% CI, 1.26, 1.67) ); heart failure HR 2.32 (95% CI, 2.14, 2.52) ; AMI HR 1.90 (95% CI, 1.69, 2.13) ); and IHD HR 1.78 (95% CI, 1.63, 1.94) (Fig. 6). The gene discussed is NPPB; the disease is heart failure.