NPPB and heart failure: When considering the secondary outcome, of the individual components of the primary composite outcome, an increased NTproBNP was associated with a statistically significant increased risk of all-cause mortality HR 2.49 (95% CI, 2.33, 2.66); stroke HR 1.49 (95% CI, 1.23, 1.70)); atrial fibrillation and flutter HR 1.96 (95% CI, 1.76, 2.17)); heart failure HR 2.26 (95% CI, 2.08, 2.44); AMI HR 1.91 (95% CI, 1.71, 2.13); and IHD HR 1.83 (95% CI, 1.69, 1.99) (Fig. 3).