In the GN sub-groups, the most significant risk associated with an increased NTproBNP was HF, over the 5 years of follow-up in: IgAN HR 2.46 (95% CI, 2.11, 2.86) and MN HR 2.43 (95% CI, 2.08, 2.84). The gene discussed is NPPB; the disease is hydrops fetalis.