The results showed that a reduced risk of migraine was related with PROCR, GSTM4, and SLC4A1(PROCR: OR(95%CI) = 0.82(0.72–0.93);p = 1.98e − 03;GSTM4:OR(95%CI) = 0.93(0.91–0.94);p = 4.21e − 17;SLC4A1:OR(95%CI) = 0.76(0.65–0.88); p = 2.41e − 04), while TNFRSF10A was related with increased migraine risk (TNFRSF10A: OR(95%CI) = 1.09(1.04–1.14); p = 1.49e − 04) (Fig. 5 and Table S9). The gene discussed is GSTM4; the disease is migraine disorder.