For immune checkpoints, the outcome of us discovered that UNC5A in GBM was positively correlated with ADORA2A, CD200, and negatively involved with CD44, CD48, while UNC5A in LGG was positively linked with CD200, TNFRSF18, TNFSF9, and negatively involved with BTLA, CD160, CD274, CD27, CD28, CD276, CD40LG, CD40, CD48, CD44, CD86, CD80, HAVCR2, CTLA4, LAIR1, ICOS, NRP1, LGALS9, PDCD1LG2, PDCD1, TNFRSF14, TMIGD2, TNFRSF9, TNFSF14, TNFSF4, VSIR (all p < 0.001; Fig. 8E). Here, ICOS is linked to glioblastoma.