In addition to the altered collagen proteins associated with the GOCC collagen-containing extracellular matrix term shared by both MCI and AD, this GOCC term also included increased laminin proteins (LAMA5, LAMC1), APOE, CLU, SMOC1, TGFBI, HTRA1, EFEMP1, NPNT, SPON1, and EMILIN1. The gene discussed is APOE; the disease is Alzheimer disease.