Proteins enriched in both CAA and plaques included many present in the matrisome protein cluster previously reported to strongly correlate with amyloid pathology, tau pathology and cognitive status (i.e., APP, APOE, SMOC1, SPON1, GPNMB, HTRA1, OLFML3, PTN, SPOCK2, NTN1, MD) [27, 37]. Here, APP is linked to amyloidosis.