HTRA1 and Alzheimer disease: In addition to the altered collagen proteins associated with the GOCC collagen-containing extracellular matrix term shared by both MCI and AD, this GOCC term also included increased laminin proteins (LAMA5, LAMC1), APOE, CLU, SMOC1, TGFBI, HTRA1, EFEMP1, NPNT, SPON1, and EMILIN1.