The PI3k/AKt pathway is a key regulator of tumour pathology, and activation of the PI3K/AKT signaling pathway promotes tumour cell proliferation, inhibits apoptosis, and is closely associated with tumour invasion and metastasis.In gastric cancer (GC) [122], ATXN2 expression influences the expression of cancer-associated gene products, thereby accelerating cancer progression. This evidence concerns the gene AKT1 and neoplasm.