ATXN2 and esophageal squamous cell carcinoma: For instance, ATXN2 has been shown to enhance the translation of TNFRSF1A by binding to m6A-modified TNFRSF1A mRNA, leading to the activation of NF-κB and MAPK pathways, thereby promoting esophageal squamous cell carcinoma (ESCC) tumorigenesis and progression [133].