However, improvements for selected diseases were obtained by including a specific predictive biomarker (captured only in the Expansion panels), such as TCN1 (a vitamin B12 binding protein) for vitamin B12 deficiency anemia, KLK3 (prostate-specific antigen) for prostate cancer or, F10 (a coagulation factor that converts prothrombin into thrombin) and PROS1 (an anticoagulant protein) for thrombophilia (Supplementary Fig. 4). Here, KLK3 is linked to thrombophilia.