KLK3 and Rare hereditary thrombophilia: However, improvements for selected diseases were obtained by including a specific predictive biomarker (captured only in the Expansion panels), such as TCN1 (a vitamin B12 binding protein) for vitamin B12 deficiency anemia, KLK3 (prostate-specific antigen) for prostate cancer or, F10 (a coagulation factor that converts prothrombin into thrombin) and PROS1 (an anticoagulant protein) for thrombophilia (Supplementary Fig. 4).