[26] prepared the HER2-targeted probe [18F]-4-fluorobenzoate (FB)]–2Rs15d by coupling the most commonly used 18F‐labeled agent, 18F-(N-succinimidyl-4-fluorobenzoate), with the nanobody 2Rs15d and then carried out in vivo biodistribution and tumor imaging studies. The gene discussed is ERBB2; the disease is neoplasm.