HMGB1 and neoplasm: Moreover, combined with the phosphoproteomic data, we observed that the phosphosites BAD/S118, RIPK2/S531, EPHA2/S897, HMGB1/S100, PRKAB1/S10, etc., enriched in tumor angiogenesis were significantly positively associated with ROCK2 (Spearman’s r > 0.2, p < 0.05), confirming the regulatory role of ROCK2 in angiogenesis (Supplementary Fig. S7a).