As a result, the overexpression of MTHFD2 or TYMS significantly enhanced the tumor cell proliferation rate (Fig. 3g and Supplementary Fig. S5a), whereas the tumor cell growth promoted by MTHFD2 or TYMS overexpression was decreased by the overexpression of MTR (Fig. 3g and Supplementary Fig. S5a). Here, MTR is linked to neoplasm.