In this study, we performed comprehensive bioinformatic investigations on the 19 ALDHs genes using the Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) and Clinical Proteomic Tumor Analysis Consortium (CPTAC)-PDC000127 cohorts and identified ALDH9A1 as a prominent player in ccRCC. Here, ALDH9A1 is linked to nonpapillary renal cell carcinoma.