According to the findings, a total of 7 molecules, namely ALDH1L1, ALDH1L2, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, and ALDH16A1 met the criterion of P lower than 0.01 and demonstrated statistical significance in relation to overall survival (OS) among ccRCC patients. This evidence concerns the gene ALDH16A1 and nonpapillary renal cell carcinoma.