Thus, here we supposed that in ccRCC, the attenuation of ALDH9A1 fails to retain NPM1 in the cytoplasm and promote its accumulation in the nuclear, leading to inhibition of IQGAP2 and subsequent activation of AKT-mTOR signaling to support tumor progression and lipid accumulation. The gene discussed is AKT1; the disease is nonpapillary renal cell carcinoma.