Thus, here we supposed that in ccRCC, the attenuation of ALDH9A1 fails to retain NPM1 in the cytoplasm and promote its accumulation in the nuclear, leading to inhibition of IQGAP2 and subsequent activation of AKT-mTOR signaling to support tumor progression and lipid accumulation. This evidence concerns the gene MTOR and nonpapillary renal cell carcinoma.