Our recent study of cells from HGPS patients and progeria mice model revealed that, the accelerated senescence of muscle stem cells is greatly associated with increased activation of cGAS-Sting innate immune signaling induced by nuclear DNA damage and leaking into cytosol [20]; however, the potential occurrence and mechanism of cellular senescence in postmitotic skeletal muscle myofibers still remains a mystery. The gene discussed is CGAS; the disease is Hutchinson-Gilford progeria syndrome.