ZMPSTE24 and progeroid syndrome: Zmpste24 is Lamin A-processing zinc metalloproteinase required for cleaving the carboxylic group of prelamin A to Lamin A. Knocking out Zmpste24 in mice (Z24−/− mice) leads to accelerated aging and aging-related pathologies common to HGPS, and this has become an important murine model for HGPS and progeria [19–21].