KLK3 and Familial prostate cancer: Panellists were uncertain over the value of offering a DRE to asymptomatic men with a normal PSA (regardless of risk factors such as family history of prostate cancer or Black ethnicity), given the relatively low positive predictive value of DRE and poor concordance between DREs performed in primary versus secondary care.21–23 However, panellists agreed that, if DRE is done, GPs should refer asymptomatic men with PSA below threshold, if the DRE is suspicious, and a man’s relevant medical history should be included in the referral.