The panel made several recommendations that conflict with current guidelines, such as proactive rather than reactive conversations about prostate cancer and PSA with men at the highest risk (Black men aged ≥45 years, men with family history of prostate cancer ≥45 years, and men with confirmed genetic risk factors ≥45 years), and recommending against routinely performing DRE in asymptomatic men. This evidence concerns the gene KLK3 and Familial prostate cancer.