KLK3 and cancer: Strongly recommend that the PSA blood test be proactively discussed with any of the following:Black men from the age of 45 years;men from the age of 45 years if they have a known family history of prostate cancer, particularly if a first-degree relative has died at a young age of this cancer; andmen from the age of 45 years if they have confirmed genetic risk factors that increase their risk of developing prostate cancer, for example, BRCA2 gene mutations