Strongly recommend that the PSA blood test be proactively discussed with any of the following:Black men from the age of 45 years;men from the age of 45 years if they have a known family history of prostate cancer, particularly if a first-degree relative has died at a young age of this cancer; andmen from the age of 45 years if they have confirmed genetic risk factors that increase their risk of developing prostate cancer, for example, BRCA2 gene mutations. The gene discussed is KLK3; the disease is prostate cancer.