Most prominently, Factor 1 showed interactions of fatty acyls like linoleic, myristic, and dodecanoic acid with the hepatocyte nuclear factor 4 alpha (HNF4A) (Supplementary Fig. S8), which were disrupted in the early hours following AKI, and subsequently seen to be recovered in the late time points (Fig. 4D and E; Supplementary Fig. S9). Here, HNF4A is linked to acute kidney injury.