We further hypothesize that ATP could be released via the transporter Pannexin 1, which was also upregulated in tumor cells (Log2FC 1.00, p.adj 2.76 × 10−4) and in turn activating purinergic receptors, such as P2RY13 (Fig. 3B and D), while further inhibiting sodium transporters, such as SCNN1 components (Fig. 3B and D). The gene discussed is SLC5A4; the disease is neoplasm.