This was demonstrated by significant indirect effects of IL-6 on the relationship between autistic traits and chronic disabling fatigue (b=1.06 (95% CI=1.03 to 1.10); figure 4A), and on the relationship between ADHD traits and chronic disabling fatigue (b=1.08 (95% CI=1.02 to 1.15); figure 4B). The gene discussed is IL6; the disease is attention deficit-hyperactivity disorder.