Berberine is a weak dopamine D1-like and D2-like receptor antagonist(D1R IC50 = 15.5 μM, D2LR IC50 = 17.1 μM, D2SR IC50 = 38.6μM) (using HTRF assay for D1R and [35S]GTPγSbinding assay for D2SR and D2LR) and amelioratesthe development of experimentally induced colitis in mice by suppressinginnate and adaptive immune responses.142. This evidence concerns the gene DRD1 and colitis.