RIOK1 and cholangiocarcinoma: Interestingly, whole-genomesequencing of cancer cells revealed that human Rio1, RIOK1, is frequentlyamplified in cancer: 7% of ovarian tumors, 3.6% of melanomas, 4.2% of mature Bcell neoplasms, 3.8% of ocular melanomas, 3.4% of bladder urothelial carcinomas,2.7% of liver hepatocellular carcinomas, 2.8% of cholangiocarcinomas, and 2.3%of mesotheliomas (The Cancer Genome Atlas (TCGA): https://www.cancer.gov/tcga, https://www.cbioportal.org).