Of the 720 genes related to ischemic stroke in Open Targets,22 103 had instrumentable protein products (P<1×10−11) in UKB Pharma Proteomics Project.17 Five of these met a false discovery rate–adjusted significance threshold in MR for incident stroke (ANGPT1, FGF5, FURIN, MMP12, and TFPI) but none in the MR of subsequent MACE. The gene discussed is ANGPT1; the disease is Stroke.