Of the 720 genes related to ischemic stroke in Open Targets,22 103 had instrumentable protein products (P<1×10−11) in UKB Pharma Proteomics Project.17 Five of these met a false discovery rate–adjusted significance threshold in MR for incident stroke (ANGPT1, FGF5, FURIN, MMP12, and TFPI) but none in the MR of subsequent MACE. This evidence concerns the gene MMP12 and ischemic stroke.