Two variants were significantly associated with subsequent cardiovascular events: rs76472767 near gene RNF220 (odds ratio, 0.75 [95% CI, 0.64–0.85]; P=3.69×10−8) with subsequent AIS and rs13294166 near gene LINC01492 (odds ratio, 1.52 [95% CI, 1.37–1.67]; P=3.77×10−8) with subsequent MACE. The gene discussed is RNF220; the disease is androgen insensitivity syndrome.