The discovery of 2 proteins having a predicted causal effect on subsequent MACE after stroke suggests that inflammation is a contributing factor to subsequent MACE outcomes after incident stroke AIS.30,31 TNFRSF14 (also known as HVEM) signals via the 9/3 pathway, which has a role in immune cell survival. This evidence concerns the gene TNFRSF14 and androgen insensitivity syndrome.