We found APOER2 Δex4-5, +ex6B, Δex18 isoform (unique to control) and APOER2 +ex6B, Δex14, Δex18 isoform (unique to AD) generated lower amounts of CTFs compared to APOER2-FL following APOE treatment (48.6% and 47.5% decrease, p = 0.0089 and p = 0.0168 respectively, Fig 6D). The gene discussed is LRP8; the disease is Alzheimer disease.