FURIN and Alzheimer disease: In contrast, neither APOER2 Δex4-5, +ex6B, Δex15 or APOER2 +ex6B, Δex14, Δex18, found in the human AD brains we analyzed, were rescued back to APOER2-FL levels of mature receptor following furin inhibition, p < 0.001 and p = 0.02, respectively (lanes 10 and 12 in Fig 5D and 5F).