To understand how APOER2 splicing changes across AD relevant brain regions, we generated APOER2-specific long-read sequencing data of hippocampal tissue from the same 3 AD patients (indicated by asterisks), and 3 age-matched controls of which one was obtained from the same individual as the parietal cortex (Fig 2A), and subjected them to the same bioinformatic pipeline as the parietal cortex samples. The gene discussed is LRP8; the disease is Alzheimer disease.