Furthermore, APOER2 Δex4-5, +ex6B, Δex15 shares a similar exon pattern to Δex4-5, +ex6B, Δex18, which was only found in control hippocampus compared to AD hippocampus, highlighting how exon inclusion patterns along the full -length of the receptor exhibit different relative read abundances in AD. Here, LRP8 is linked to Alzheimer disease.