We found a significant reduction in APOER2 ex15 inclusion in the parietal cortex of female APOE ɛ3/ɛ3 AD brains compared to control p = 0.0285, with a similar decreasing trend observed in male APOE ɛ3/ɛ3 AD brains, p = 0.2311 and those of both genders, p = 0.0536 (Fig 4D). The gene discussed is APOE; the disease is Alzheimer disease.