CASP8 and Zika virus infectious disease: Notably, ZIKV infection led to a noticeable increase in cleaved caspase-8 (Fig 6D, lane 7 vs lane 5) on day 4 (S4C and S4D Fig), and in cleaved caspase-3 (Fig 6D, lane 7 vs lane 5) on day 4 (S4E Fig) post-infection in WT macrophages.