Based on the quantification, the ratio of cleaved caspase-8 and caspase-3 to total caspase-8 and caspase-3 is significantly lower in the c-FLIP knockdown group compared to the control group upon ZIKV infection while no significant was observed in non-infected group (S5A–S5C Fig). This evidence concerns the gene CASP8 and Zika virus infectious disease.