The term high-grade B-cell lymphoma with dual rearrangements of MYC and BCL2 and/or BCL6 from the previous edition of WHO has been conceptually reframed and reassigned to diffuse large B-cell lymphoma/high-grade B-cell lymphoma with MYC and BCL2 rearrangements (DLBCL/HGBL-MYC/BCL2). This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.