DR genes: COMP can promote the proliferation, invasion, and metastasis of breast cancer cells and has a certain impact on the occurrence and progression of breast cancer [62]; ADIPOQ, as an anti-tumor protein, plays an important role in regulating the apoptosis, metabolism, and immune response of tumor cells, and its level is closely related to the prognosis of breast cancer patients [63]. This evidence concerns the gene COMP and breast cancer.