Although there was no difference in the expression of DHX35 after infection with RNA virus and transfection with the synthetic nucleic acid analogs poly(I:C) and poly(dA:dT), DHX35 translocated into the cytosol from the nucleus where it recognized cytosolic poly(I:C) and poly(dA:dT) and interacted with RIG-I and MAVS to enhance the production of IFN-β, IL6, and CXCL10 in human airway epithelial cells, albeit the mechanism of DHX35 translocation is unknown. The gene discussed is RIGI; the disease is infection.