In univariate analysis, older age (β = −1.16, P < 0.001) and membranous LN (β = −22.2, P = 0.012) were significantly associated with a shorter time to IS D/C, while higher baseline eGFR (β = 0.25, P = 0.043) and low C3 levels (β = 17.1, P = 0.032) were significantly associated with longer time. The gene discussed is C3; the disease is lobular neoplasia.