INS and type 2 diabetes mellitus: Only five out of 19 miRNAs that are dysregulated in liver of obese T2D subjects and are associated with at least one metabolic trait (HbA1c, fasting glucose, insulin, NAS, serum triglycerides) after adjustment for confounding factors (age, sex, BMI, and NAS) are conserved in mice (Figure 1E, Supplementary file 1f).