Loss of LRP6-mediated activation of the Wnt/beta-catenin signaling pathway (Figure 5) enhances hepatic lipid accumulation by increasing de novo lipogenesis and triglyceride synthesis (Thompson and Monga, 2007; Liu et al., 2011) which is in line with the observed increased expression of SCD in T2D obese humans and SCD and FASN in HepG2 cells after miR-182–5 p mimic transfection. The gene discussed is CTNNB1; the disease is type 2 diabetes mellitus.