IRS1 and type 2 diabetes mellitus: The hepatic expression of Lrp6, Insr, Irs1, Ppara, and Pck1 was significantly reduced in HFD-fed mice compared to chow controls (Figure 3C) which is consistent with the increased expression of miR-182–5 p and the regulation of these target genes - except for INSR - in obese T2D human livers.