ACE and hydrops fetalis: There are several drugs that make up guideline-directed medical therapy (GDMT), including beta-blockers (BBs), RASi (renin–angiotensin–aldosterone inhibitors) including ACEi (Angiotensin-Converting Enzyme Inhibitor), ARB (Angiotensin Receptor Blocker) or ARNi (Angiotensin Receptor-Nephrilysin inhibitor), MRA (Mineralocorticoid Receptor Antagonist), and SGLT (sodium-glucose cotransporter) inhibitors, that have an undisputedly proven positive clinical effect, especially among patients with HF with reduced ejection fraction (HFrEF) [1, 2].