Among the detected variants, 5 were in known cancer predisposition genes (TP53, MUTYH, FANCC, DICER1, and FANCA), while one patient harbored a variant in MYO3A, and another one in MYO5B. Both the latter genes belong to the myosin family, and functional loss of MYO3A and MYO5B disrupts cell polarity and causes malformation of cochlea hairs and microvillus leading to deafness and microvillus inclusion disease, respectively [26, 27]. The gene discussed is MYO5B; the disease is cancer.