We determined the role of myeloid cell α9β1 in early atherosclerosis in two models: α9Mye-KOApoe−/− or the Ldlr−/− mice transplanted with bone marrow (BM) from α9Mye-KO mice fed a high-fat “Western” diet for 4 wk. The gene discussed is LDLR; the disease is atherosclerosis.