FMO5 and atherosclerosis: It has been demonstrated that upon recruitment to the growing plaque, neutrophils undergo activation characterized by the generation of reactive oxygen species via the NADPH oxidase activity, a process associated with suicidal rather than vital NETosis (reviewed).28 Considering that suicidal NETosis requires the induction of the ERK signaling pathway17 and this pathway can be induced via the ligation of integrin α9β1,18 we hypothesized that integrin α9β1 can mediate suicidal NETosis in atherosclerosis.