At this stage, hair follicles begin to grow and develop, API5 functions to inhibit apoptosis, and API5 expression increases; Numerous studies have demonstrated that API5 is up-regulated in human cancers of the cervix, prostate, lung, colon, and other related tissues in mouse fibroblasts, and has significant anti-apoptotic ability (22, 24–26). The gene discussed is API5; the disease is cancer.