TAAR1 agonists had overall positive and large effects compared to control conditions on locomotor activity in animal models of psychosis (N=13, number of experiments k=41; SMD=1.01, 95% CI: 0.74, 1.27) with point estimates of SMDs for individual compounds ranging from 0.46 for LK000746 to 1.61 for R05256390 (Figure 5A). This evidence concerns the gene TAAR1 and psychotic disorder.