Porphyria Cutanea Tarda (PCT) is the most common cutaneous porphyria and manifests as photosensitivity, blistering, skin fragility, erosions, milia, and crusts on sun-exposed body areas.1, 2, 3 PCT is a hepatocutaneous disease of heme synthesis in which uroporphyrinogen decarboxylase (UROD) has reduced activity, resulting in the accumulation of porphyrins and heme intermediates in the liver and skin.1 The gene discussed is UROD; the disease is cutaneous porphyria.