LEP and type 2 diabetes mellitus: However, a study of patients with T2DM and prediabetes patients reported that the CV intake for 12 months decreased plasma leptin levels (Martins et al., 2023), while another study reported decreases in leptin levels in obese mice treated with Parachlorella beijerinckii, an algae that is also used as a food supplement (Noguchi et al., 2013).