Employing the hepatic fibrosis mouse model, Gong et al. have demonstrated that MALAT1 recruits DNMT1 to the Glis2 promoter to induce DNA methylation, thereby downregulating Glis2 by repressing Glis2 transcription in trans and activating hepatic stellate cells to aggravate hepatic fibrosis [41]. This evidence concerns the gene GLIS2 and Hepatic fibrosis.