HNRNPA1 and colorectal carcinoma: Mechanistic studies have revealed that the HOXB-AS3-peptide interacts with the hnRNPA1 protein and sequesters hnRNPA1 to modulate alternative splicing of pyruvate kinase M (PKM), resulting in the decreased PKM2 isoform inhibiting CRC growth (Fig. 1G) [78].