Investigations examining the impact of intense physical activity on the intestines as well as initial brain damage after subarachnoid hemorrhage revealed the preventive benefits of resveratrol and netrin-1, respectively, through the Nrf2/FTH1/GPX4 and PPARγ/Nrf2/GPX4 cascade [27,28]. This evidence concerns the gene GPX4 and subarachnoid hemorrhage.